碘甲烷 → 苯甲酸

HRID 13491

反应方程式

HRID 13491 反应方程式
CNC=O.N([C:8]1[CH:9]=[C:10]([CH:14]=[CH:15][CH:16]=1)[C:11]([OH:13])=[O:12])=C=S.IC>CO>[C:11]([OH:13])(=[O:12])[C:10]1[CH:14]=[CH:15][CH:16]=[CH:8][CH:9]=1

参与物

5

反应物 3

HCID 6328碘甲烷HCID 31254N-甲基甲酰胺HCID 750463-羧基异硫氰酸苯酯

产物 1

HCID 243苯甲酸

试剂、催化剂与溶剂 1

HCID 887(5BETA,17BETA)-17-羟基-17-(甲基-D3)-2'H-雄甾-2-烯并[3,2-C]吡唑-5'(1'H)-酮溶剂

反应条件

温度
60 °C

实验过程

To 4-[3-amino-4-(methylamino)phenoxy](2-pyridyl)}-N-methylcarboxamide (1 eq) in methanol was added 3-isothiocyanatobenzoic acid (1 eq) and stirred at 60° C. for 3 h. To it was then added iodomethane (1 eq) and heated to 60° C. for 3 h and concentrated the solvent and purified on silica gel to yield 3-({1-methyl-5-[2-(N-methylcarbamoyl)(4-pyridyloxy))]benzimidazol-2-yl}amino)benzoic acid. MS: MH+=417.

后处理

  1. concentrationconcentrated the solvent
  2. custompurified on silica gel

来源与证据

ORD记录
ord-bf3d1cacbe2b4322bcf5fee1703039c8
来源数据集
uspto-grants-2010_06
专利号
US07728010B2

关联笔记

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