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乙醇 → Ethyl 3-nitro-4-(trifluoromethyl)benzoate
参与物
| 角色 | 名称 | HCID | 投料 |
|---|---|---|---|
| 反应物 | 乙醇 | HCID 702 | — |
| 反应物 | 四氧化硫 | HCID 1118 | — |
| 反应物 | 3-硝基-4-三氟甲基苯甲酸 | HCID 2779015 | — |
| 溶剂 | 聚[6-[4-(4-氰基苯基)苯氧基]己基甲基丙烯酸酯] | HCID 962 | — |
| 溶剂 | 乙酸乙酯 | HCID 8857 | — |
| 产物 | Ethyl 3-nitro-4-(trifluoromethyl)benzoate | HCID 19783148 | — |
反应步骤
3-Nitro-4-(trifluoromethyl)benzoic acid (10 g, 43 mmol) was taken up in 100 ml of ethanol and sulfuric acid (11 ml) was added to the mixture. The reaction was heated to reflux for 12 hours. The volatiles were removed in vacuo. The residue obtained was diluted with ethyl acetate and water. The layers were separated and the organic layer was washed with an aqueous solution of saturated sodium bicarbonate, water and brine. The organic layer was then dried with sodium sulfate and the volatiles removed in vacuo to give ethyl 3-nitro-4-(trifluoromethyl)benzoate a clear yellow oil.
来源与证据
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 专利号 | US07880000B2 |
| 来源数据集 | uspto-grants-2011_02 |
| ORD ID | ord-239bb387f3e949059ac6268ec44f034b |
| 来源说明 | uspto-grants-2011_02 |