5-chloro-1-methyl-1H-indole-3-carbaldehyde → 5-chloro-1-methyl-3-(methylaminomethyl)-1H-indole

HRID 1362002笔记

反应方程式

HRID 1362002 反应方程式
BrC1C=C[C:5](NCC(OC)=O)=[N:6]C=1.[Cl:14][C:15]1[CH:16]=[C:17]2[C:21](=[CH:22][CH:23]=1)[N:20]([CH3:24])[CH:19]=[C:18]2[CH:25]=O>>[Cl:14][C:15]1[CH:16]=[C:17]2[C:21](=[CH:22][CH:23]=1)[N:20]([CH3:24])[CH:19]=[C:18]2[CH2:25][NH:6][CH3:5]

参与物

3

反应物 2

HCID 167237965-chloro-1-methyl-1H-indole-3-carbaldehydeHCID 22139049甲基 2-[(5-溴吡啶-2-基)氨基]醋酸盐

产物 1

HCID 221390175-chloro-1-methyl-3-(methylaminomethyl)-1H-indole收率 93%

实验过程

According to the procedure of Preparation 13 (c), except substituting 5-chloro-1-methyl-1H-indole-3-carboxaldehyde for the, 3-dimethyl-1H-indole-2-carboxaldehyde, the title compound (2.1 g, 93%) was obtained as an amber oil: MS (ES) m/e 209.0 (M+H)+.

来源与证据

ORD记录
ord-e9af886dc3084fdd815b2ac20e4246be
来源数据集
uspto-grants-2011_02
专利号
US07879872B2

反应笔记

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