3-N-叔丁氧羰基胺基环丁胺 → tert-butyl N-[1-(2-methoxy-4-pyridinyl)azetidin-3-yl]carbamate

HRID 137

反应方程式

HRID 137 反应方程式
CC(C)(C)OC(=O)NC1CNC1.COc1cc(Br)ccn1>CC(C)(C)[O-].Cc1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Na+].[Pd].[Pd].c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1>COc1cc(N2CC(NC(=O)OC(C)(C)C)C2)ccn1

参与物

7

反应物 2

HCID 15194053-N-叔丁氧羰基胺基环丁胺HCID 140623094-溴-2-甲氧基吡啶

产物 1

HCID 118055029tert-butyl N-[1-(2-methoxy-4-pyridinyl)azetidin-3-yl]carbamate收率 99.96%

试剂、催化剂与溶剂 4

HCID 23676156叔丁醇钠试剂HCID 6348761,1'-联萘-2,2'-双二苯膦 (BINAP)催化剂HCID 9811564三(二亚苄基丙酮)二钯催化剂HCID 1140甲苯溶剂

反应条件

温度
70 °C

实验过程

A mixture of all the reactants in toluene was heated in a sealed vial at 70 °C overnight. According to LC-MS the reaction was completed and the product had been formed. Toluene was removed, water was added and the product was extracted with DCM. The organic phase was dried through phase separator and concentrated.

来源与证据

ORD记录
ord-f3ebf4dfde174cff92751e3b49ce74da
来源数据集
750 AstraZeneca ELN dataset
原始链接
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关联笔记

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