海萝胶 → (3-Bromo-4-((1-isoquinolinylcarbonyl)amino)phenyl)acetic acid

HRID 1372720

反应方程式

HRID 1372720 反应方程式
[Br:1][C:2]1[CH:3]=[C:4]([CH2:21][C:22]([O:24]CC)=[O:23])[CH:5]=[CH:6][C:7]=1[NH:8][C:9]([C:11]1[C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[CH:14]=[CH:13][N:12]=1)=[O:10].[OH-].[Na+].Cl>C1COCC1>[Br:1][C:2]1[CH:3]=[C:4]([CH2:21][C:22]([OH:24])=[O:23])[CH:5]=[CH:6][C:7]=1[NH:8][C:9]([C:11]1[C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[CH:14]=[CH:13][N:12]=1)=[O:10]

参与物

5

反应物 3

HCID 313海萝胶HCID 14798二甲基对苯二胺二盐酸HCID 58778618Ethyl (3-bromo-4-((1-isoquinolinylcarbonyl)amino)phenyl)acetate

产物 1

HCID 17859108(3-Bromo-4-((1-isoquinolinylcarbonyl)amino)phenyl)acetic acid收率 98.1%

试剂、催化剂与溶剂 1

HCID 8028四氢呋喃溶剂

实验过程

Ethyl (3-bromo-4-((1-isoquinolinylcarbonyl)amino)phenyl)acetate (1.64 g, 3.97 mmol) was dissolved in THF (40 ml). To the resulting solution was added 0.25N NaOH (24.0 ml, 5.95 mmol), and the mixture was stirred at room temperature for 8 hours. The reaction mixture was poured into 1N HCl (50 ml) to acidify the mixture. The crystals thus precipitated were collected by filtration under reduced pressure, washed with water, and dried under reduced pressure to give (3-bromo-4-((1-isoquinolinylcarbonyl)amino)phenyl)acetic acid (1.50 g, 98%) as a pale yellow solid.

后处理

  1. customThe crystals thus precipitated
  2. filtrationwere collected by filtration under reduced pressure
  3. washwashed with water
  4. customdried under reduced pressure

来源与证据

ORD记录
ord-32f773e534ce42acac00bdeb04ff47cd
来源数据集
uspto-grants-2007_01
专利号
US07157487B2

关联笔记

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