四氢呋喃 → (5-Chloro-2-fluoro-4-((2-methyl-3-indazolylcarbonyl)amino)phenyl)acetic acid

HRID 1372743

反应方程式

HRID 1372743 反应方程式
[Cl:1][C:2]1[C:3]([NH:15][C:16]([C:18]2[N:19]([CH3:27])[N:20]=[C:21]3[C:26]=2[CH:25]=[CH:24][CH:23]=[CH:22]3)=[O:17])=[CH:4][C:5]([F:14])=[C:6]([CH2:8][C:9]([O:11]CC)=[O:10])[CH:7]=1.C1COCC1.[OH-].[Na+]>Cl>[Cl:1][C:2]1[C:3]([NH:15][C:16]([C:18]2[N:19]([CH3:27])[N:20]=[C:21]3[C:26]=2[CH:25]=[CH:24][CH:23]=[CH:22]3)=[O:17])=[CH:4][C:5]([F:14])=[C:6]([CH2:8][C:9]([OH:11])=[O:10])[CH:7]=1

参与物

5

反应物 3

HCID 8028四氢呋喃HCID 14798二甲基对苯二胺二盐酸HCID 58778670Ethyl (5-chloro-2-fluoro-4-((2-methyl-3-indazolylcarbonyl)amino)phenyl)acetate

产物 1

HCID 17859380(5-Chloro-2-fluoro-4-((2-methyl-3-indazolylcarbonyl)amino)phenyl)acetic acid收率 340%

试剂、催化剂与溶剂 1

HCID 313海萝胶溶剂

实验过程

To ethyl (5-chloro-2-fluoro-4-((2-methyl-3-indazolylcarbonyl)amino)phenyl)acetate (390 mg, 1.00 mmol) were added THF (10 ml) and 0.25N NaOH (6.00 ml, 1.50 mmol). The resulting mixture was stirred at room temperature for 16 hours. The reaction mixture was poured in 1N HCl (1.5 ml). The crystals thus precipitated were collected by filtration under reduced pressure, washed with water and dried under reduced pressure to give (5-chloro-2-fluoro-4-((2-methyl-3-indazolylcarbonyl)amino)phenyl)acetic acid (1.23 g, 95%) as a brown solid.

后处理

  1. customThe crystals thus precipitated
  2. filtrationwere collected by filtration under reduced pressure
  3. washwashed with water
  4. customdried under reduced pressure

来源与证据

ORD记录
ord-fb42eba0e7c840a88088eb6d27343210
来源数据集
uspto-grants-2007_01
专利号
US07157487B2

关联笔记

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