水合肼 → 2,3,4,5-四氢-6(4-氯苯基)-3(2H-)-吡嗪酮

HRID 1491

反应方程式

HRID 1491 反应方程式
[Cl:1][C:2]1[CH:14]=[CH:13][C:5]([C:6]([CH2:8][CH2:9][C:10](O)=[O:11])=O)=[CH:4][CH:3]=1.O.[NH2:16][NH2:17]>C(O)C>[Cl:1][C:2]1[CH:14]=[CH:13][C:5]([C:6]2[CH2:8][CH2:9][C:10](=[O:11])[NH:16][N:17]=2)=[CH:4][CH:3]=1

参与物

4

反应物 2

HCID 24654水合肼HCID 776043-(4-氯苯甲酰)丙酸

产物 1

HCID 1209902,3,4,5-四氢-6(4-氯苯基)-3(2H-)-吡嗪酮收率 80%

试剂、催化剂与溶剂 1

HCID 702乙醇溶剂

实验过程

To a solution of 3-(4-chlorobenzoyl)propionic acid (20g) in absolute ethanol (200 ml) was added 5 g of hydrazine monohydrate. A thick solid was formed which dissolved after heating. The resulting solution was refluxed for 3 h, cooled and the solid formed filtered and dried to yield 16 g (80%) of 6-(4-chlorophenyl)-4,5-dihydropyridazinone.

后处理

  1. customA thick solid was formed which
  2. dissolutiondissolved
  3. temperatureafter heating
  4. temperatureThe resulting solution was refluxed for 3 h
  5. temperaturecooled
  6. customthe solid formed
  7. filtrationfiltered
  8. customdried

来源与证据

ORD记录
ord-cd96027b0a0d43cfb4c23e75a82d466d
来源数据集
uspto-grants-1998_03
专利号
US05726162

关联笔记

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