过氧化二苯甲酰 → 2,3,5,6-四氟溴苄

HRID 1607928

反应方程式

HRID 1607928 反应方程式
[F:1][C:2]1[C:7]([F:8])=[CH:6][C:5]([F:9])=[C:4]([F:10])[C:3]=1[CH3:11].[Br:12]N1C(=O)CCC1=O.C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1>C(Cl)(Cl)(Cl)Cl>[F:1][C:2]1[C:7]([F:8])=[CH:6][C:5]([F:9])=[C:4]([F:10])[C:3]=1[CH2:11][Br:12]

参与物

5

反应物 3

HCID 7187过氧化二苯甲酰HCID 67184N-溴代丁二酰亚胺(NBS)HCID 788962,3,5,6-四氟甲苯

产物 1

HCID 1043772,3,5,6-四氟溴苄

试剂、催化剂与溶剂 1

HCID 5943四氯化碳溶剂

反应条件

温度
25 °C

实验过程

A mixture of 2,3,5,6-tetrafluorotoluene (1.7 g), N-bromosuccinimide (1.9 g), dry carbon tetrachloride (10 ml) and benzoyl peroxide (0.01 g) was heated at the reflux temperature for 20 hours, cooled to the ambient temperature (ca. 25° C.) filtered and the filtrate diluted with diethyl ether. The ethereal solution was washed with water, dried over anhydrous magnesium sulphate and concentrated by evaporation of the solvents to yield 2,3,5,6-tetrafluorobenzyl bromide as a mobile colourlessoil.

后处理

  1. temperaturewas heated at the reflux temperature for 20 hours
  2. filtrationfiltered
  3. additionthe filtrate diluted with diethyl ether
  4. washThe ethereal solution was washed with water
  5. dry with materialdried over anhydrous magnesium sulphate
  6. concentrationconcentrated by evaporation of the solvents

来源与证据

ORD记录
ord-1e894d1a67874e6783eab0da040c1559
来源数据集
uspto-grants-1989_09
专利号
US04868209

关联笔记

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