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5-氰基-2-糠醛 → 5-(羟甲基)呋喃-2-甲腈
参与物
| 角色 | 名称 | HCID | 投料 |
|---|---|---|---|
| 反应物 | 5-氰基-2-糠醛 | HCID 642139 | — |
| 反应物 | 硼氢化钾 | HCID 4192641 | — |
| 反应物 | 磷酸二氢钠 | HCID 23672064 | — |
| 溶剂 | 聚[6-[4-(4-氰基苯基)苯氧基]己基甲基丙烯酸酯] | HCID 962 | — |
| 溶剂 | 四氢呋喃 | HCID 8028 | — |
| 产物 | 5-(羟甲基)呋喃-2-甲腈 | HCID 3021406 | 87.1% |
反应步骤
0.87 g of the aldehyde of Stage A in 5 ml of tetrahydrofuran and 1 ml of water was cooled to 0° C. and 0.47 g of potassium borohydride were introduced. The mixture was stirred for 5 hours, poured into an aqueous sodium dihydrogenphosphate solution and extracted with isopropyl ether. The extract was dried and the solvent was evaporated to obtain 0.77 g of the expected product.
来源与证据
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 专利号 | US05405865 |
| 来源数据集 | uspto-grants-1995_04 |
| ORD ID | ord-5e604ca6abc64148b01f7f7b4b997bd6 |
| 来源说明 | uspto-grants-1995_04 |