5-氰基-2-糠醛 → 5-(羟甲基)呋喃-2-甲腈

HRID 1654130

反应方程式

HRID 1654130 反应方程式
[CH:1]([C:3]1[O:7][C:6]([C:8]#[N:9])=[CH:5][CH:4]=1)=[O:2].[BH4-].[K+].P([O-])(O)(O)=O.[Na+]>O1CCCC1.O>[OH:2][CH2:1][C:3]1[O:7][C:6]([C:8]#[N:9])=[CH:5][CH:4]=1

参与物

6

反应物 3

HCID 6421395-氰基-2-糠醛HCID 4192641硼氢化钾HCID 23672064磷酸二氢钠

产物 1

HCID 30214065-(羟甲基)呋喃-2-甲腈收率 87.1%

试剂、催化剂与溶剂 2

HCID 962聚[6-[4-(4-氰基苯基)苯氧基]己基甲基丙烯酸酯]溶剂HCID 8028四氢呋喃溶剂

实验过程

0.87 g of the aldehyde of Stage A in 5 ml of tetrahydrofuran and 1 ml of water was cooled to 0° C. and 0.47 g of potassium borohydride were introduced. The mixture was stirred for 5 hours, poured into an aqueous sodium dihydrogenphosphate solution and extracted with isopropyl ether. The extract was dried and the solvent was evaporated to obtain 0.77 g of the expected product.

后处理

  1. extractionextracted with isopropyl ether
  2. customThe extract was dried
  3. customthe solvent was evaporated

来源与证据

ORD记录
ord-5e604ca6abc64148b01f7f7b4b997bd6
来源数据集
uspto-grants-1995_04
专利号
US05405865

关联笔记

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