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(5BETA,17BETA)-17-羟基-17-(甲基-D3)-2'H-雄甾-2-烯并[3,2-C]吡唑-5'(1'H)-酮 → HCID 178443814，化合物
参与物
| 角色 | 名称 | HCID | 投料 |
|---|---|---|---|
| 反应物 | (5BETA,17BETA)-17-羟基-17-(甲基-D3)-2'H-雄甾-2-烯并[3,2-C]吡唑-5'(1'H)-酮 | HCID 887 | — |
| 反应物 | 聚[6-[4-(4-氰基苯基)苯氧基]己基甲基丙烯酸酯] | HCID 962 | — |
| 反应物 | Government regulation | HCID 24408 | — |
| 反应物 | 三硫代碳酸钠 | HCID 101753 | — |
| 反应物 | 氯乙酸异辛酯 | HCID 3084517 | — |
| 产物 | HCID 178443814 | HCID 178443814 | — |
反应步骤
In a double-walled glass reactor equipped with a stirring system, a thermometer, an equilibrated bromine ampoule and a condenser surmounted with a gas-lock, 108.2 g of a 35.26% aqueous solution of sodium trithiocarbonate (0.25 mole), 50 ml of methanol and 25.3 g of water were placed. 51.5 g of isooctylchloroacetate (0.25 mole) diluted in 25 ml of methanol was then added dropwise, while maintaining the temperature of the reaction mixture from 15° to 20° C. At the end of the addition, the mixture was stirred for 1 hour at the same temperature. A two-phase mixture was obtained.
来源与证据
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 专利号 | US04307028 |
| 来源数据集 | uspto-grants-1981_12 |
| ORD ID | ord-b1467c67c01445819a1c334c1c99d543 |
| 来源说明 | uspto-grants-1981_12 |