(5BETA,17BETA)-17-羟基-17-(甲基-D3)-2'H-雄甾-2-烯并[3,2-C]吡唑-5'(1'H)-酮 → HCID 178443814，化合物

HRID 1660092

反应方程式

HRID 1660092 反应方程式
BrBr.[C:3](=[S:6])([S-:5])[S-:4].[Na+:7].[Na+].O.[CH2:10]([O:18][C:19](=[O:22])CCl)[CH2:11][CH2:12][CH2:13][CH2:14][CH:15]([CH3:17])[CH3:16].[CH3:23]O>>[CH2:10]([O:18][C:19]([SH:6]([CH3:23])[C:3]([S-:5])=[S:4])=[O:22])[CH2:11][CH2:12][CH2:13][CH2:14][CH:15]([CH3:16])[CH3:17].[Na+:7]

参与物

6

反应物 5

HCID 887(5BETA,17BETA)-17-羟基-17-(甲基-D3)-2'H-雄甾-2-烯并[3,2-C]吡唑-5'(1'H)-酮2 次HCID 962聚[6-[4-(4-氰基苯基)苯氧基]己基甲基丙烯酸酯]HCID 24408Government regulationHCID 101753三硫代碳酸钠HCID 3084517氯乙酸异辛酯

产物 1

HCID 178443814HCID 178443814，化合物

实验过程

In a double-walled glass reactor equipped with a stirring system, a thermometer, an equilibrated bromine ampoule and a condenser surmounted with a gas-lock, 108.2 g of a 35.26% aqueous solution of sodium trithiocarbonate (0.25 mole), 50 ml of methanol and 25.3 g of water were placed. 51.5 g of isooctylchloroacetate (0.25 mole) diluted in 25 ml of methanol was then added dropwise, while maintaining the temperature of the reaction mixture from 15° to 20° C. At the end of the addition, the mixture was stirred for 1 hour at the same temperature. A two-phase mixture was obtained.

后处理

  1. customIn a double-walled glass reactor equipped with a stirring system
  2. additionwas then added dropwise
  3. temperaturewhile maintaining the temperature of the reaction mixture from 15° to 20° C
  4. additionAt the end of the addition
  5. customA two-phase mixture was obtained

来源与证据

ORD记录
ord-b1467c67c01445819a1c334c1c99d543
来源数据集
uspto-grants-1981_12
专利号
US04307028

关联笔记

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