化工社化工社化学信息打印报告 · 仅供科研参考
2-氨基-4-甲基吡啶 → 2-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-N-(4-methyl-pyridin-2-yl)acetamide
参与物
| 角色 | 名称 | HCID | 投料 |
|---|---|---|---|
| 反应物 | 2-氨基-4-甲基吡啶 | HCID 1533 | — |
| 反应物 | 三乙胺 | HCID 8471 | — |
| 反应物 | 胸腺嘧啶-1-乙酸 | HCID 853753 | — |
| 反应物 | Methanaminium, N-((1H-benzotriazol-1-yloxy)(dimethylamino)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 2733084 | — |
| 溶剂 | N,N-二甲基甲酰胺 | HCID 6228 | — |
| 产物 | 2-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-N-(4-methyl-pyridin-2-yl)acetamide | HCID 24745170 | — |
反应步骤
A mixture of 2-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetic acid (75 mg, 0.4 mmol), 4-methylpyridin-2-amine (44 mg, 0.4 mmol), HBTU (151 mg, 0.4 mmol) and 0.1 mL of Et3N in DMF (5 mL) was stirred at room temperature for 2 hours to provide the title compound, which was then purified by HPLC. 1H NMR (400 MHz, DMSO-d6) δ: 11.37 (s, 1H), 10.97 (s, 1H), 8.20 (d, J=8.0 Hz, 1H), 7.81 (s, 1H), 7.51 (s, 1H), 7.03 (d, J=8.0 Hz, 1H), 4.58 (s, 2H), 2.33 (s, 3H), 1.77 (s, 3H). [M+H] calc'd for C13H14N4O2, 275; found, 275.
来源与证据
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 专利号 | US08034822B2 |
| 来源数据集 | uspto-grants-2011_10 |
| ORD ID | ord-45ccae9971ee40cc8e3ac3e0296fb6a9 |
| 来源说明 | uspto-grants-2011_10 |