盐酸 → 4-(1-Benzyl-piperidin-4-ylidenemethyl)-benzimidic acid ethyl ester

HRID 1663237笔记

反应方程式

HRID 1663237 反应方程式
[CH2:1]([N:8]1[CH2:13][CH2:12][C:11](=[CH:14][C:15]2[CH:22]=[CH:21][C:18]([C:19]#[N:20])=[CH:17][CH:16]=2)[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(Cl)(Cl)Cl.Cl.[CH2:28]([OH:30])[CH3:29]>>[CH2:28]([O:30][C:19](=[NH:20])[C:18]1[CH:17]=[CH:16][C:15]([CH:14]=[C:11]2[CH2:12][CH2:13][N:8]([CH2:1][C:2]3[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=3)[CH2:9][CH2:10]2)=[CH:22][CH:21]=1)[CH3:29]

参与物

5

反应物 4

HCID 313盐酸HCID 702乙醇HCID 6212三氯甲烷HCID 674356554-(1-Benzyl-piperidin-4-ylidenemethyl)-benzonitrile

产物 1

HCID 674362034-(1-Benzyl-piperidin-4-ylidenemethyl)-benzimidic acid ethyl ester收率 92.4%

实验过程

A mixture of 4-(1-benzyl-piperidin-4-ylidenemethyl)-benzonitrile (14 g, 48.6 mmol), chloroform (10 mL) and 6 M hydrogen chloride in ethanol (300 mL) was stirred at room temperature for 48 hours. The solution was concentrated in vacuo, the remaining solid was repeatedly dissolved in ethanol (400 mL) and concentrated in vacuo to yield 16.4 g (92.4%) of the title compound, which was used in the next steps without further purification.

后处理

  1. concentrationThe solution was concentrated in vacuo
  2. dissolutionthe remaining solid was repeatedly dissolved in ethanol (400 mL)
  3. concentrationconcentrated in vacuo

来源与证据

ORD记录
ord-491d251fbdd64308bae3659291581e66
来源数据集
uspto-grants-2011_10
专利号
US08034827B2

反应笔记

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