六水硝酸铽 → HCID 57433540，化合物

HRID 1671663笔记

反应方程式

HRID 1671663 反应方程式
[N+:1]([O-:4])(O)=[O:2].[F:5][C:6]1[CH:15]=[C:14]([NH:16][C:17]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][N:20]=2)=[O:18])[CH:13]=[CH:12][C:7]=1[C:8]([O:10][CH3:11])=[O:9]>C(=O)([O-])[O-].[Na+].[Na+]>[F:5][C:6]1[CH:15]=[C:14]([NH:16][C:17]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][N:20]=2)=[O:18])[C:13]([N+:1]([O-:4])=[O:2])=[CH:12][C:7]=1[C:8]([O:10][CH3:11])=[O:9]

参与物

4

反应物 2

HCID 944六水硝酸铽HCID 57433539Methyl 2-fluoro-4-[(2-pyridinylcarbonyl)amino]benzoate

产物 1

HCID 57433540HCID 57433540，化合物

试剂、催化剂与溶剂 1

HCID 10340Carbonic acid sodium salt (1:2)溶剂

实验过程

With cooling with ice, fuming nitric acid (110 ml) was gradually added to methyl 2-fluoro-4-[(2-pyridinylcarbonyl)amino]benzoate (27.7 g), and stirred at room temperature for 1.5 hours. With cooling with ice, the reaction liquid was gradually added to an aqueous solution (2000 ml) of sodium carbonate (138 g), and the formed solid was taken out through filtration. After dried under reduced pressure, the entitled compound was obtained as a yellow solid.

后处理

  1. temperatureWith cooling with ice
  2. customthe reaction liquid
  3. filtrationthe formed solid was taken out through filtration
  4. customAfter dried under reduced pressure
  5. customthe entitled compound was obtained as a yellow solid

来源与证据

ORD记录
ord-f19ca06b113e4f64808c7f7153e5b9a6
来源数据集
uspto-grants-2011_08
专利号
US07994331B2

反应笔记

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