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甲酸 → 膦胺霉素
参与物
| 角色 | 名称 | HCID | 投料 |
|---|---|---|---|
| 反应物 | 甲酸 | HCID 284 | — |
| 反应物 | 乙酐 | HCID 7918 | — |
| 反应物 | 氢氧化镁 | HCID 73981 | — |
| 反应物 | 3-(N-HYDROXYAMINO)PROPYL PHOSPHONATE | HCID 342170 | — |
| 溶剂 | 聚[6-[4-(4-氰基苯基)苯氧基]己基甲基丙烯酸酯] | HCID 962 | — |
| 产物 | 膦胺霉素 | HCID 572 | 65.8% |
反应步骤
An oily 3-(N-formyl-N-hydroxyamino)propylphosphonic acid (12.05 g.), which was prepared by the reaction of 3-(N-hydroxyamino)propylphosphonic acid (15.5 g.), acetic anhydride (12.3 g.) and formic acid (9.8 ml.) conducted in substantially the same manner as that of Example (31), was dissolved in water (80 ml.) and treated with magnesium hydroxide (5.83 g.) for 15 minutes under ice-cooling with stirring.
来源与证据
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 专利号 | US04206156 |
| 来源数据集 | uspto-grants-1980_06 |
| ORD ID | ord-d0d185827fa64e5797039853d4dfd715 |
| 来源说明 | uspto-grants-1980_06 |