甲酸 → 膦胺霉素

HRID 1706221

反应方程式

HRID 1706221 反应方程式
[OH:1][NH:2][CH2:3][CH2:4][CH2:5][P:6](=[O:9])([OH:8])[OH:7].[C:10](OC(=O)C)(=[O:12])C.C(O)=O.[OH-].[Mg+2].[OH-]>O>[CH:10]([N:2]([CH2:3][CH2:4][CH2:5][P:6](=[O:8])([OH:7])[OH:9])[OH:1])=[O:12]

参与物

6

反应物 4

HCID 284甲酸HCID 7918乙酐HCID 73981氢氧化镁HCID 3421703-(N-HYDROXYAMINO)PROPYL PHOSPHONATE

产物 1

HCID 572膦胺霉素收率 65.8%

试剂、催化剂与溶剂 1

HCID 962聚[6-[4-(4-氰基苯基)苯氧基]己基甲基丙烯酸酯]溶剂

实验过程

An oily 3-(N-formyl-N-hydroxyamino)propylphosphonic acid (12.05 g.), which was prepared by the reaction of 3-(N-hydroxyamino)propylphosphonic acid (15.5 g.), acetic anhydride (12.3 g.) and formic acid (9.8 ml.) conducted in substantially the same manner as that of Example (31), was dissolved in water (80 ml.) and treated with magnesium hydroxide (5.83 g.) for 15 minutes under ice-cooling with stirring.

后处理

  1. temperaturecooling

来源与证据

ORD记录
ord-d0d185827fa64e5797039853d4dfd715
来源数据集
uspto-grants-1980_06
专利号
US04206156

关联笔记

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