1-甲基吲哚-2-甲酸 → 1-甲基-2-吲哚甲酰氯

HRID 17153

反应方程式

HRID 17153 反应方程式
[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[C:3]1[C:11]([OH:13])=O.C(Cl)(=O)C([Cl:17])=O>ClCCl.CN(C)C=O>[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[C:3]1[C:11]([Cl:17])=[O:13]

参与物

5

反应物 2

HCID 276951-甲基吲哚-2-甲酸HCID 65578草酰氯

产物 1

HCID 123033141-甲基-2-吲哚甲酰氯

试剂、催化剂与溶剂 2

HCID 6228N,N-二甲基甲酰胺催化剂HCID 6344二氯甲烷溶剂

反应条件

温度
0 °C

实验过程

A suspension of 1-methyl-1H-2-indolecarboxylic acid (0.485 g, 2.769 mmol) in dichloromethane (10 mL) at 0° C. was treated with oxalyl chloride (0.369 g, 2.91 mmol) and one drop of dimethyl formamide. The reaction mixture was stirred at 0° C. for 1 hour and at room temperature for 2 hours. The solvent was removed under reduced pressure and dried on the high vacuum for 1 hour. The residue was used directly in the subsequent reaction without further purification or analysis.

后处理

  1. customThe solvent was removed under reduced pressure
  2. customdried on the high vacuum for 1 hour
  3. customThe residue was used directly in the subsequent reaction without further purification or analysis

来源与证据

ORD记录
ord-582438ec3357466097420a38f45a9681
来源数据集
uspto-grants-2010_06
专利号
US07737160B2

关联笔记

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