Government regulation → 5-Bromo-2-methyl-4-(4-nitrophenyl)-1,3-thiazole

HRID 1727770

反应方程式

HRID 1727770 反应方程式
[Br:1]Br.[CH3:3][C:4]1[S:5][CH:6]=[C:7]([C:9]2[CH:14]=[CH:13][C:12]([N+:15]([O-:17])=[O:16])=[CH:11][CH:10]=2)[N:8]=1>C(Cl)(Cl)Cl>[Br:1][C:6]1[S:5][C:4]([CH3:3])=[N:8][C:7]=1[C:9]1[CH:10]=[CH:11][C:12]([N+:15]([O-:17])=[O:16])=[CH:13][CH:14]=1

参与物

4

反应物 2

HCID 24408Government regulationHCID 1936892-甲基-4-(4-硝基苯基)噻唑

产物 1

HCID 689981005-Bromo-2-methyl-4-(4-nitrophenyl)-1,3-thiazole收率 60%

试剂、催化剂与溶剂 1

HCID 6212三氯甲烷溶剂

实验过程

Bromine (6 mmol) was added dropwise to a solution of 2-methyl-4-(4-nitrophenyl)-1,3-thiazole (5 mmol) in chloroform (20 mL) and the solution refluxed for 4 h. The solvent was evaporated and the product purified by crystallization from ether to afford the title compound (60%). ESMS [M+H]+: 300.2

后处理

  1. temperaturethe solution refluxed for 4 h
  2. customThe solvent was evaporated
  3. customthe product purified by crystallization from ether

来源与证据

ORD记录
ord-d0c34458662e4028bdddffb6d44372ca
来源数据集
uspto-grants-2009_02
专利号
US07495102B2

关联笔记

加载中…