碘 → HCID 178418276，化合物

HRID 1750

反应方程式

HRID 1750 反应方程式
[Mg:1].II.[Br:4]CCBr.Br[C:9]1[CH:14]=CC(OC)=[CH:11][CH:10]=1.[CH2:17]1[CH2:21][O:20][CH2:19][CH2:18]1>>[CH2:11]([Mg:1][Br:4])[C:10]1[CH:18]=[CH:17][C:21]([O:20][CH3:19])=[CH:14][CH:9]=1

参与物

6

反应物 5

HCID 807碘HCID 77304-溴苯甲醚HCID 78391,2-二溴乙烷HCID 8028四氢呋喃HCID 5462224Magnesium

产物 1

HCID 178418276HCID 178418276，化合物

反应条件

温度
20 °C

实验过程

Magnesium (36 g, 1.5 mol), iodine (a few crystals) and THF (1 L) were heated under nitrogen, with stirring, at reflux for 15 min. The mixture was cooled to 20° C., stirring stopped, and 1,2-dibromoethane (2.5 ml) added. After an exothermic reaction was observed (a few min) stirring was restarted which was accompanied by a rise in temperature to 35° C. The mixture was cooled to 20° C. and 4-bromoanisole slowly added over 1 h at 14°-18° C. with cooling. Stirring was continued for 10 min after the addition was complete.

后处理

  1. temperatureat reflux for 15 min
  2. stirringstirring
  3. customAfter an exothermic reaction
  4. stirringstirring
  5. customwas accompanied by a rise in temperature to 35° C
  6. temperatureThe mixture was cooled to 20° C.
  7. temperaturewith cooling
  8. stirringStirring
  9. additionafter the addition

来源与证据

ORD记录
ord-f12406699295447fa245b2a1d83d7703
来源数据集
uspto-grants-1998_03
专利号
US05726315

关联笔记

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