吡唑 → 1-(4-(三氟甲基)苯基)-1H-吡唑

HRID 1751925笔记

反应方程式

HRID 1751925 反应方程式
[NH:1]1[CH:5]=[CH:4][CH:3]=[N:2]1.Cl[C:7]1[CH:12]=[CH:11][C:10]([C:13]([F:16])([F:15])[F:14])=[CH:9][CH:8]=1>>[F:14][C:13]([F:16])([F:15])[C:10]1[CH:11]=[CH:12][C:7]([N:1]2[CH:5]=[CH:4][CH:3]=[N:2]2)=[CH:8][CH:9]=1

参与物

3

反应物 2

HCID 1048吡唑HCID 7394对氯三氟甲苯

产物 1

HCID 112180941-(4-(三氟甲基)苯基)-1H-吡唑

实验过程

Following General Procedure A (140° C., 24 hours), 1H-pyrazole (102 mg, 1.5 mmol) is coupled with 1-chloro-4-(trifluoromethyl)benzene (134 μL, 1.0 mmol). The crude brown oil is purified by flash chromatography on silica gel (eluent: dichloromethane/hexanes=50/50) to provide 80 mg (38% isolated yield) of the desired product as a white solid.

后处理

  1. customThe crude brown oil is purified by flash chromatography on silica gel (eluent: dichloromethane/hexanes=50/50)
  2. customto provide

来源与证据

ORD记录
ord-b8c3e9a1055949e8986ee55e31a19680
来源数据集
uspto-grants-2015_10
专利号
US09162953B2

反应笔记

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