乙酐 → 2-ACETAMIDO-5-FLUOROTOLUENE

HRID 17546笔记

反应方程式

HRID 17546 反应方程式
C(O[C:5](=[O:7])[CH3:6])(=O)C.[F:8][C:9]1[CH:15]=[CH:14][C:12]([NH2:13])=[C:11]([CH3:16])[CH:10]=1>C(Cl)(Cl)Cl>[F:8][C:9]1[CH:15]=[CH:14][C:12]([NH:13][C:5](=[O:7])[CH3:6])=[C:11]([CH3:16])[CH:10]=1

参与物

4

反应物 2

HCID 7918乙酐HCID 679824-氟-2-甲基苯胺

产物 1

HCID 27376232-ACETAMIDO-5-FLUOROTOLUENE收率 99.8%

试剂、催化剂与溶剂 1

HCID 6212三氯甲烷溶剂

实验过程

Acetic anhydride (17.7 ml, 0.19 mol) was dropwise added to 4-fluoro-2-methylaniline (234 g, 0.19 mol). The solidified reaction mixture was dissolved in chloroform, washed with an aqueous saturated sodium hydrogencarbonate solution and saturated brine, then dried over anhydrous sodium sulfate. The solvent was evaporated away under reduced pressure, and the residue was dried with a vacuum pump to obtain the entitled compound (31.7 g, 99%) as a pale red solid.

后处理

  1. customThe solidified reaction mixture
  2. washwashed with an aqueous saturated sodium hydrogencarbonate solution and saturated brine
  3. dry with materialdried over anhydrous sodium sulfate
  4. customThe solvent was evaporated away under reduced pressure
  5. customthe residue was dried with a vacuum pump

来源与证据

ORD记录
ord-b28a3fb55f434213817c419a6f86b40a
来源数据集
uspto-grants-2010_06
专利号
US07737166B2

反应笔记

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