六水硝酸铽 → N-(4-fluoro-2-methyl-6-nitrophenyl)acetamide

HRID 17547笔记

反应方程式

HRID 17547 反应方程式
[N+:1]([O-:4])(O)=[O:2].[F:5][C:6]1[CH:11]=[CH:10][C:9]([NH:12][C:13](=[O:15])[CH3:14])=[C:8]([CH3:16])[CH:7]=1>C(O)(=O)C>[F:5][C:6]1[CH:11]=[C:10]([N+:1]([O-:4])=[O:2])[C:9]([NH:12][C:13](=[O:15])[CH3:14])=[C:8]([CH3:16])[CH:7]=1

参与物

4

反应物 2

HCID 944六水硝酸铽HCID 27376232-ACETAMIDO-5-FLUOROTOLUENE

产物 1

HCID 54330341N-(4-fluoro-2-methyl-6-nitrophenyl)acetamide收率 87%

试剂、催化剂与溶剂 1

HCID 176醋酸溶剂

实验过程

With cooling with ice, fuming nitric acid (25 ml) was dropwise added to an acetic acid (100 ml) solution of N-(4-fluoro-2-methylphenyl)acetamide (I-259) (10.0 g, 59.8 mmol), taking 50 minutes. After the addition, then restoration to room temperature and stirring for 23 hours, the reaction liquid was poured into ice. The precipitated solid was collected by filtration, washed with water, then dried to obtain the entitled compound (11.1 g, 87%) as a pale brown solid.

后处理

  1. additionAfter the addition
  2. customthe reaction liquid
  3. additionwas poured into ice
  4. filtrationThe precipitated solid was collected by filtration
  5. washwashed with water
  6. customdried

来源与证据

ORD记录
ord-c0b4e5a56fc740aabdc16f007c2e158d
来源数据集
uspto-grants-2010_06
专利号
US07737166B2

反应笔记

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