N,N-二甲基甲酰胺 → 6-Amino-3-bromo-4-fluoro-2-methylbenzonitrile
反应方程式
[Br:1]N1C(=O)CCC1=O.CN(C)C=O.[NH2:14][C:15]1[CH:22]=[C:21]([F:23])[CH:20]=[C:19]([CH3:24])[C:16]=1[C:17]#[N:18]>O>[NH2:14][C:15]1[C:16]([C:17]#[N:18])=[C:19]([CH3:24])[C:20]([Br:1])=[C:21]([F:23])[CH:22]=1参与物
5
实验过程
N-Bromosuccinimide (16.6 g, 93.3 mmol) was gradually added to an N,N-dimethylformamide (250 ml) solution of 2-amino-4-fluoro-6-methylbenzonitrile (I-264) (14.0 g, 93.3 mmol). After stirring for 6 hours, the reaction liquid was poured into water with ice (750 ml), the precipitated solid was collected by filtration. The solid was washed with water, then dried to obtain the entitled compound (20.2 g, 95%) as a gray solid.
后处理
- customthe reaction liquid
- filtrationthe precipitated solid was collected by filtration
- washThe solid was washed with water
- customdried
来源与证据
- ORD记录
- ord-dc698879c22a4075bb6d951fdb6285db
- 来源数据集
- uspto-grants-2010_06
- 专利号
- US07737166B2
反应笔记
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