Government regulation → HCID 14125892，化合物

HRID 1761890笔记

反应方程式

HRID 1761890 反应方程式
[C:1]1([C:7]2[CH:12]=[CH:11][C:10]([C:13]([CH2:15][CH2:16][CH2:17][Cl:18])=[O:14])=[CH:9][CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Br:19]Br>C(O)(=O)C>[C:1]1([C:7]2[CH:12]=[CH:11][C:10]([C:13]([CH:15]([Br:19])[CH2:16][CH2:17][Cl:18])=[O:14])=[CH:9][CH:8]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

参与物

4

反应物 2

HCID 24408Government regulationHCID 122875581-Butanone, 1-[1,1'-biphenyl]-4-yl-4-chloro-

产物 1

HCID 14125892HCID 14125892，化合物

试剂、催化剂与溶剂 1

HCID 176醋酸溶剂

实验过程

246 g (0.95 mol) of 3-chloropropyl 4-phenylphenyl ketone in 380 ml of glacial acetic acid were placed in a reaction flask and 152 g (0.95 mol) of bromine were added dropwise at 30° C., the reaction commencing with dissolution and decolorization. After 1 hour, a thick precipitate deposited. The mixture was stirred for a further 4 hours at room temperature in order to complete the reaction. The crystals produced were filtered off under suction, washed with water, dissolved in dichloromethane, washed by shaking with NaHCO3 solution and water and dried, and 250 g (78% of theory) of the title substance were obtained as colorless crystals of melting point 85°-88° C.

后处理

  1. dissolutionthe reaction commencing with dissolution and decolorization
  2. customthe reaction
  3. customThe crystals produced
  4. filtrationwere filtered off under suction
  5. washwashed with water
  6. dissolutiondissolved in dichloromethane
  7. washwashed
  8. stirringby shaking with NaHCO3 solution and water
  9. customdried
  10. custom250 g (78% of theory) of the title substance were obtained as colorless crystals of melting point 85°-88° C.

来源与证据

ORD记录
ord-8667b01de8eb4dc28a469c06b315aa42
来源数据集
uspto-grants-1989_05
专利号
US04829075

反应笔记

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