N-甲基哌嗪 → HCID 21959580，化合物

反应方程式

[C:1]([C:5]1[CH:10]=[CH:9][C:8]([N+:11]([O-:13])=[O:12])=[CH:7][C:6]=1[Br:14])([CH3:4])([CH3:3])[CH3:2].[CH3:15][N:16]1[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]1>>[Br:14][C:6]1[C:5]([C:1]([CH3:4])([CH3:2])[CH3:3])=[CH:10][C:9]([N:19]2[CH2:20][CH2:21][N:16]([CH3:15])[CH2:17][CH2:18]2)=[C:8]([N+:11]([O-:13])=[O:12])[CH:7]=1

参与物

反应物 2

HCID 53167N-甲基哌嗪

HCID 2385871-(叔丁基)-2-溴-4-硝基苯

产物 1

HCID 21959580HCID 21959580，化合物

反应条件

温度: 130 °C

实验过程

A mixture of 1-(tert-butyl)-2-bromo-4-nitrobenzene (3 g) and N-methylpiperazine (8 g) was heated neat at 130° C. for 4 h. The residue was purified by column chromatography to give 1-[4-bromo-5-(tert-butyl)-2-nitrophenyl]-4-methylpiperazine, which was hydrogenated to furnish 4-(tert-butyl)-2-(4-methylpiperazinyl)-phenylamine.

后处理

customThe residue was purified by column chromatography

来源与证据

ORD记录: ord-cd637d6bf2b4458493c8bead9ac43302
来源数据集: uspto-grants-2009_03
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US07507748B2

反应笔记

加载中…

参与物