2-苯甲基烟酸 → 2-Phenylpiperidin-3-amine

反应方程式

C1(C2N=CC=CC=2C(O)=O)C=CC=CC=1.[C:16]1([C:22]2[C:27]([NH2:28])=[CH:26][CH:25]=[CH:24][N:23]=2)[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>>[C:16]1([CH:22]2[CH:27]([NH2:28])[CH2:26][CH2:25][CH2:24][NH:23]2)[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1

参与物

反应物 2

HCID 974892-苯甲基烟酸

HCID 27627842-苯基-3-氨基吡啶

产物 1

HCID 97940082-Phenylpiperidin-3-amine

实验过程

First, a carboxyl group of a 2-phenylnicotinic acid derivative is amidated and applied to Hofmann's reaction. Then, the resulting 2-phenyl-3-aminopyridine derivative is reduced to produce a 2-phenyl-3-aminopiperidine derivative, and further subjecting the resulting compound to acylation or alkylation, if desired.

后处理

customapplied to Hofmann's reaction

来源与证据

ORD记录: ord-d470a022d26b4b1aba454715856cc860
来源数据集: uspto-grants-2006_06
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US07067535B2

反应笔记

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