草酰氯单甲酯 → HCID 71208654，化合物

HRID 1887828笔记

反应方程式

HRID 1887828 反应方程式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:11])[CH2:9][CH3:10])=[C:4]([NH:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH:3]=1.Cl[C:20](=[O:25])[C:21]([O:23][CH3:24])=[O:22]>C1(C)C=CC=CC=1>[CH3:24][O:23][C:21](=[O:22])[C:20]([N:12]([C:4]1[CH:3]=[C:2]([F:1])[CH:7]=[CH:6][C:5]=1[C:8](=[O:11])[CH2:9][CH3:10])[C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1)=[O:25]

参与物

4

反应物 2

HCID 79846草酰氯单甲酯HCID 71208293HCID 71208293，化合物

产物 1

HCID 71208654HCID 71208654，化合物

试剂、催化剂与溶剂 1

HCID 1140甲苯溶剂

反应条件

温度
110 °C

实验过程

To a solution of 1-(4-fluoro-2-phenylamino-phenyl)-propan-1-one (6.0 g, 24.7 mmol) in toluene (75 mL) was added methyl chlorooxoacetate (14.2 mL, 148 mmol) at room temperature under nitrogen. The reaction mixture was heated at reflux at 110° C. for 16 hr. The reaction mixture was concentrated under vacuum to afford N-(5-fluoro-2-propionyl-phenyl)-N-phenyl-oxalamic acid methyl ester. The crude product was used in the next step without further purification.

后处理

  1. temperatureThe reaction mixture was heated
  2. concentrationThe reaction mixture was concentrated under vacuum

来源与证据

ORD记录
ord-4d9663461e394b7b9525502a46cbb910
来源数据集
uspto-grants-2013_08
专利号
US08501732B2

反应笔记

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