6-Isopropylamino-5-methyl-nicotinic acid isopropyl ester → 6-(Isopropylamino)-5-methylnicotinic acid
反应方程式
C([O:4][C:5](=[O:17])[C:6]1[CH:11]=[C:10]([CH3:12])[C:9]([NH:13][CH:14]([CH3:16])[CH3:15])=[N:8][CH:7]=1)(C)C>Cl>[CH:14]([NH:13][C:9]1[C:10]([CH3:12])=[CH:11][C:6]([C:5]([OH:17])=[O:4])=[CH:7][N:8]=1)([CH3:16])[CH3:15]参与物
3
实验过程
A solution of 6-isopropylamino-5-methyl-nicotinic acid isopropyl ester (137 mg, 0.58 mmol) in 25% aq. HCl (5 mL) is stirred at 65° C. for 24 h before it is concentrated and dried to give the title compound (133 mg) as a yellow solid; LC-MS: tR=0.57 min, [M+1]+=195.54.
后处理
- concentrationis concentrated
- customdried
来源与证据
- ORD记录
- ord-920dc38bc9f043c7a445c051de7d7f6c
- 来源数据集
- uspto-grants-2013_12
- 专利号
- US08598208B2
反应笔记
加载中…