碘甲烷 → 苯甲酸

HRID 1915667

反应方程式

HRID 1915667 反应方程式
NC1C=C(C=CC=1NC)OC1C=CN=C(C(NC)=O)C=1.N([C:24]1[CH:32]=[CH:31][C:27]([C:28]([OH:30])=[O:29])=[CH:26][CH:25]=1)=C=S.IC>CO>[C:28]([OH:30])(=[O:29])[C:27]1[CH:31]=[CH:32][CH:24]=[CH:25][CH:26]=1

参与物

5

反应物 3

HCID 6328碘甲烷HCID 2429464-羧基苯基异硫氰酸酯HCID 177558384-(3-Amino-4-methylamino-phenoxy)-pyridine-2-carboxylic acid methylamide

产物 1

HCID 243苯甲酸

试剂、催化剂与溶剂 1

HCID 887(5BETA,17BETA)-17-羟基-17-(甲基-D3)-2'H-雄甾-2-烯并[3,2-C]吡唑-5'(1'H)-酮溶剂

反应条件

温度
60 °C

实验过程

To {4-[3-amino-4-(methylamino)phenoxy](2-pyridyl)}-N-methylcarboxamide (1 eq) in methanol was added 4-isothiocyanatobenzoic acid (1 eq) and stirred at 60° C. for 3 h. To it was then added iodomethane (1 eq) and heated to 60° C. for 3 h. and concentrated the solvent and purified on silica gel to yield 4-({1-methyl-5-[2-(N-methylcarbamoyl)(4-pyridyloxy))]benzimidazol-2-yl}amino)benzoic acid. MS: MH+=417.

后处理

  1. concentrationconcentrated the solvent
  2. custompurified on silica gel

来源与证据

ORD记录
ord-63de2332865b46bf8ac8f4e3de0d1956
来源数据集
uspto-grants-2013_12
专利号
US08614330B2

关联笔记

加载中…