氯化亚砜 → 3-i-propyl-1-(chloromethyl)-1H-pyrazole hydrochloride

HRID 1982994笔记

反应方程式

HRID 1982994 反应方程式
[CH:1]([C:4]1[CH:8]=[CH:7][N:6]([CH2:9]O)[N:5]=1)([CH3:3])[CH3:2].S(Cl)([Cl:13])=O>ClCCl>[ClH:13].[CH:1]([C:4]1[CH:8]=[CH:7][N:6]([CH2:9][Cl:13])[N:5]=1)([CH3:3])[CH3:2]

参与物

4

反应物 2

HCID 24386氯化亚砜HCID 23149190[3-(propan-2-yl)-1H-pyrazol-1-yl]methanol

产物 1

HCID 231491783-i-propyl-1-(chloromethyl)-1H-pyrazole hydrochloride

试剂、催化剂与溶剂 1

HCID 6344二氯甲烷溶剂

实验过程

1.28 g of 3-i-propyl-1H-pyrazole-1-ylmethanol was dissolved to 20 ml of dichloromethane. 2 ml of thionyl chloride was added to the solution, followed by stirring at room temperature for overnight. The reaction mixture was concentrated under reduced pressure to obtain 1.58 g of 3-i-propyl-1-(chloromethyl)-1H-pyrazole hydrochloride.

后处理

  1. concentrationThe reaction mixture was concentrated under reduced pressure

来源与证据

ORD记录
ord-c6f5aa9115c248108b26d7c6ed139dad
来源数据集
uspto-grants-2009_06
专利号
US07541374B2

反应笔记

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