氯化亚砜 → 3-t-butyl-1-(chloromethyl)-1H-pyrazole hydrochloride
反应方程式
[C:1]([C:5]1[CH:9]=[CH:8][N:7]([CH2:10]O)[N:6]=1)([CH3:4])([CH3:3])[CH3:2].S(Cl)([Cl:14])=O>ClCCl>[ClH:14].[C:1]([C:5]1[CH:9]=[CH:8][N:7]([CH2:10][Cl:14])[N:6]=1)([CH3:4])([CH3:3])[CH3:2]参与物
4
实验过程
1.07 g of 3-t-butyl-1H-pyrazole-1-ylmethanol was dissolved to 140 ml of dichloromethane. 2 ml of thionyl chloride was added to the solution, followed by stirring at room temperature for overnight. The reaction mixture was concentrated under reduced pressure to obtain 1.66 g of 3-t-butyl-1-(chloromethyl)-1H-pyrazole hydrochloride.
后处理
- concentrationThe reaction mixture was concentrated under reduced pressure
来源与证据
- ORD记录
- ord-71f639c4cb5c455398ba3d9b56928875
- 来源数据集
- uspto-grants-2009_06
- 专利号
- US07541374B2
反应笔记
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