Diethyl [4-(7-benzyl-3-methylxanthin-1-yl)butyl]phosphonate → Diethyl [4-(3-methylxanthin-1-yl)butyl]phosphonate

HRID 2017笔记

反应方程式

HRID 2017 反应方程式
C([N:8]1[C:16]2[C:15](=[O:17])[N:14]([CH2:18][CH2:19][CH2:20][CH2:21][P:22](=[O:29])([O:26][CH2:27][CH3:28])[O:23][CH2:24][CH3:25])[C:13](=[O:30])[N:12]([CH3:31])[C:11]=2[N:10]=[CH:9]1)C1C=CC=CC=1>C(O)C.[Pd]>[CH3:31][N:12]1[C:11]2[N:10]=[CH:9][NH:8][C:16]=2[C:15](=[O:17])[N:14]([CH2:18][CH2:19][CH2:20][CH2:21][P:22](=[O:29])([O:23][CH2:24][CH3:25])[O:26][CH2:27][CH3:28])[C:13]1=[O:30]

参与物

4

反应物 1

HCID 22446297Diethyl [4-(7-benzyl-3-methylxanthin-1-yl)butyl]phosphonate

产物 1

HCID 22446315Diethyl [4-(3-methylxanthin-1-yl)butyl]phosphonate

试剂、催化剂与溶剂 2

HCID 23938钯碳催化剂HCID 702乙醇溶剂

实验过程

15.7 g (0.035 mol) of diethyl [4-(7-benzyl-3-methylxanthin-1-yl)butyl]-phosphonate were hydrogenated in 150 ml of ethanol over 1 g of palladium (10%) on active carbon at room temperature in the course of 8 hours. The catalyst was filtered off, the filtrate was concentrated under reduced pressure and the residue was crystallized from diisopropyl ether.

后处理

  1. filtrationThe catalyst was filtered off
  2. concentrationthe filtrate was concentrated under reduced pressure
  3. customthe residue was crystallized from diisopropyl ether

来源与证据

ORD记录
ord-ecb037eb61a74599a6353b1d72d5a468
来源数据集
uspto-grants-1998_03
专利号
US05728686

反应笔记

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