4-氯异硫氰酸苯酯 → N-(4-chlorophenyl)-3-methylpiperazine-1-carbothioamide

HRID 20275

反应方程式

HRID 20275 反应方程式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]=[C:9]=[S:10])=[CH:4][CH:3]=1.[CH3:11][CH:12]1[CH2:17][NH:16][CH2:15][CH2:14][NH:13]1>ClCCl>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]([N:16]2[CH2:15][CH2:14][NH:13][CH:12]([CH3:11])[CH2:17]2)=[S:10])=[CH:4][CH:3]=1

参与物

4

反应物 2

HCID 164804-氯异硫氰酸苯酯HCID 660572-甲基哌嗪

产物 1

HCID 59347497N-(4-chlorophenyl)-3-methylpiperazine-1-carbothioamide

试剂、催化剂与溶剂 1

HCID 6344二氯甲烷溶剂2 次

实验过程

A solution of 4-chlorophenyl isothiocyanate (8.0 g, 47.17 mmol) in dichloromethane (250 mL) was added dropwise over 30 minutes to an ice cooled solution of 2-methylpiperazine (9.45 g, 94.33 mmol) in dichloromethane (250 mL). Once the addition was complete, the reaction was stirred at room temperature for an hour. The reaction was then washed with water (3×), dried over MgSO4 and concentrated under reduced pressure, to give the title compound as a white solid, 11.8 g.

后处理

  1. additionOnce the addition
  2. washThe reaction was then washed with water (3×)
  3. dry with materialdried over MgSO4
  4. concentrationconcentrated under reduced pressure

来源与证据

ORD记录
ord-5f9a14faca964707886135ffa8096e54
来源数据集
uspto-grants-2010_06
专利号
US07745630B2

关联笔记

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