乙醚 → HCID 62498593，化合物

HRID 2111478

反应方程式

HRID 2111478 反应方程式
[Cl:1][C:2]1[CH:3]=[C:4]([C:8]2[O:12][C:11]([CH:13]=[O:14])=[CH:10][CH:9]=2)[CH:5]=[CH:6][CH:7]=1.C[Mg+].[Br-].[CH3:18]COCC>C1COCC1>[Cl:1][C:2]1[CH:3]=[C:4]([C:8]2[O:12][C:11]([CH:13]([OH:14])[CH3:18])=[CH:10][CH:9]=2)[CH:5]=[CH:6][CH:7]=1

参与物

5

反应物 3

HCID 3283乙醚HCID 6098225-(3-氯苯)糠醛HCID 178418689HCID 178418689，化合物

产物 1

HCID 62498593HCID 62498593，化合物

试剂、催化剂与溶剂 1

HCID 8028四氢呋喃溶剂

实验过程

To a solution of 5-(3-chlorophenyl)furan-2-carbaldehyde (1.0 equiv.) in THF at 0° C. was added MeMgBr in ether (3.0 equiv.) and stirred for 45 min. The reaction was quenched with water, diluted with ether and filtered through Celite. The organic layer was separated and washed with brine, dried over MgSO4, and concentrated to give the 1-[5-(3-chlorophenyl)-2-furyl]ethan-1-ol.

后处理

  1. customThe reaction was quenched with water
  2. additiondiluted with ether
  3. filtrationfiltered through Celite
  4. customThe organic layer was separated
  5. washwashed with brine
  6. dry with materialdried over MgSO4
  7. concentrationconcentrated

来源与证据

ORD记录
ord-91b98511bff74a6a8e5fcf415860793e
来源数据集
uspto-grants-2009_04
专利号
US07521062B2

关联笔记

加载中…