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乙醚 → 1-[5-(3-Chlorophenyl)-2-furyl]ethan-1-ol
参与物
| 角色 | 名称 | HCID | 投料 |
|---|---|---|---|
| 反应物 | 乙醚 | HCID 3283 | — |
| 反应物 | 5-(3-氯苯)糠醛 | HCID 609822 | — |
| 反应物 | HCID 178418689 | HCID 178418689 | — |
| 溶剂 | 四氢呋喃 | HCID 8028 | — |
| 产物 | 1-[5-(3-Chlorophenyl)-2-furyl]ethan-1-ol | HCID 62498593 | — |
反应步骤
To a solution of 5-(3-chlorophenyl)furan-2-carbaldehyde (1.0 equiv.) in THF at 0° C. was added MeMgBr in ether (3.0 equiv.) and stirred for 45 min. The reaction was quenched with water, diluted with ether and filtered through Celite. The organic layer was separated and washed with brine, dried over MgSO4, and concentrated to give the 1-[5-(3-chlorophenyl)-2-furyl]ethan-1-ol.
来源与证据
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 专利号 | US07521062B2 |
| 来源数据集 | uspto-grants-2009_04 |
| ORD ID | ord-91b98511bff74a6a8e5fcf415860793e |
| 来源说明 | uspto-grants-2009_04 |