海萝胶 → 5-(4-Chlorophenyl)pyrimidin-2(1H)-one

HRID 2124

反应方程式

HRID 2124 反应方程式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[CH:11]N(C)C)[CH:9]=O)=[CH:4][CH:3]=1.[NH2:15][C:16]([NH2:18])=[O:17].Cl.[Cl-].[NH4+]>C(O)C.O>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:11]=[N:15][C:16](=[O:17])[NH:18][CH:9]=2)=[CH:4][CH:3]=1

参与物

7

反应物 4

HCID 313海萝胶HCID 1176聚脲HCID 25517氯化铵HCID 34489722-(4-Chlorophenyl)-3-(dimethylamino)acrylaldehyde

产物 1

HCID 136055385-(4-Chlorophenyl)pyrimidin-2(1H)-one收率 29.7%

试剂、催化剂与溶剂 2

HCID 702乙醇溶剂HCID 962聚[6-[4-(4-氰基苯基)苯氧基]己基甲基丙烯酸酯]溶剂

实验过程

A mixture of 2-(4-chlorophenyl)dimethylaminopropenal (Example 145a) (5.13 g), urea (2.4 g), concentrated HCl (10 ml), water (4 ml) and ethanol (150 ml) was refluxed for 4 hours. After cooling to room temperature concentrated ammonium chloride was added until the pH was 7. The resulting yellow solid was filtered off and dried yielding 1.5 g of 5-(4-chlorophenyl)-2-pyrimidinone.

后处理

  1. temperaturewas refluxed for 4 hours
  2. additionwas added until the pH was 7
  3. filtrationThe resulting yellow solid was filtered off
  4. customdried

来源与证据

ORD记录
ord-682083a1fe1b4917a49c1da58af0cb59
来源数据集
uspto-grants-1998_03
专利号
US05728698

关联笔记

加载中…