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海萝胶 → 5-(4-Chlorophenyl)pyrimidin-2(1H)-one
参与物
| 角色 | 名称 | HCID | 投料 |
|---|---|---|---|
| 反应物 | 海萝胶 | HCID 313 | — |
| 反应物 | 聚脲 | HCID 1176 | — |
| 反应物 | 氯化铵 | HCID 25517 | — |
| 反应物 | 2-(4-Chlorophenyl)-3-(dimethylamino)acrylaldehyde | HCID 3448972 | — |
| 溶剂 | 乙醇 | HCID 702 | — |
| 溶剂 | 聚[6-[4-(4-氰基苯基)苯氧基]己基甲基丙烯酸酯] | HCID 962 | — |
| 产物 | 5-(4-Chlorophenyl)pyrimidin-2(1H)-one | HCID 13605538 | 29.7% |
反应步骤
A mixture of 2-(4-chlorophenyl)dimethylaminopropenal (Example 145a) (5.13 g), urea (2.4 g), concentrated HCl (10 ml), water (4 ml) and ethanol (150 ml) was refluxed for 4 hours. After cooling to room temperature concentrated ammonium chloride was added until the pH was 7. The resulting yellow solid was filtered off and dried yielding 1.5 g of 5-(4-chlorophenyl)-2-pyrimidinone.
来源与证据
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 专利号 | US05728698 |
| 来源数据集 | uspto-grants-1998_03 |
| ORD ID | ord-682083a1fe1b4917a49c1da58af0cb59 |
| 来源说明 | uspto-grants-1998_03 |