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溴化氰 → 2-氨基苯并咪唑
参与物
| 角色 | 名称 | HCID | 投料 |
|---|---|---|---|
| 反应物 | 溴化氰 | HCID 10476 | — |
| 反应物 | 二甲基对苯二胺二盐酸 | HCID 14798 | — |
| 反应物 | 1,2-二氨基-3-甲氧基苯 | HCID 184268 | — |
| 溶剂 | 乙醇 | HCID 702 | — |
| 溶剂 | 聚[6-[4-(4-氰基苯基)苯氧基]己基甲基丙烯酸酯] | HCID 962 | — |
| 产物 | 2-氨基苯并咪唑 | HCID 13624 | — |
反应步骤
Cyanogen bromide (7.05 mmol, 0.74 g) was added to a solution of 2,3-diaminoanisole (4.7 mmol, 0.65 g) in EtOH (10 mL) and the reaction was stirred at room temperature for 14 h. The reaction was diluted with H2O and then basified (pH>12) using 4 M NaOH. The aqueous layer was extracted with CH2Cl2. The organic phase was then separated and washed with brine and then dried over MgSO4 and then concentrated to provide 2-aminobenzimidazole 37b.
来源与证据
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 专利号 | US08207173B2 |
| 来源数据集 | uspto-grants-2012_06 |
| ORD ID | ord-4dd7d82b92d54646aeddc463d3d6f37d |
| 来源说明 | uspto-grants-2012_06 |