溴化氰 → 2-氨基苯并咪唑

HRID 221519

反应方程式

HRID 221519 反应方程式
[N:1]#[C:2]Br.[NH2:4][C:5]1[C:10]([NH2:11])=[CH:9][CH:8]=[CH:7][C:6]=1OC.[OH-].[Na+]>CCO.O>[NH2:1][C:2]1[NH:4][C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:10]=2[N:11]=1

参与物

6

反应物 3

HCID 10476溴化氰HCID 14798二甲基对苯二胺二盐酸HCID 1842681,2-二氨基-3-甲氧基苯

产物 1

HCID 136242-氨基苯并咪唑

试剂、催化剂与溶剂 2

HCID 702乙醇溶剂HCID 962聚[6-[4-(4-氰基苯基)苯氧基]己基甲基丙烯酸酯]溶剂

实验过程

Cyanogen bromide (7.05 mmol, 0.74 g) was added to a solution of 2,3-diaminoanisole (4.7 mmol, 0.65 g) in EtOH (10 mL) and the reaction was stirred at room temperature for 14 h. The reaction was diluted with H2O and then basified (pH>12) using 4 M NaOH. The aqueous layer was extracted with CH2Cl2. The organic phase was then separated and washed with brine and then dried over MgSO4 and then concentrated to provide 2-aminobenzimidazole 37b.

后处理

  1. extractionThe aqueous layer was extracted with CH2Cl2
  2. customThe organic phase was then separated
  3. washwashed with brine
  4. dry with materialdried over MgSO4
  5. concentrationconcentrated

来源与证据

ORD记录
ord-4dd7d82b92d54646aeddc463d3d6f37d
来源数据集
uspto-grants-2012_06
专利号
US08207173B2

关联笔记

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