聚[6-[4-(4-氰基苯基)苯氧基]己基甲基丙烯酸酯] → 3-(4-Chlorophenoxy)-2-methyl-5-(methylsulfonyl)-1H-indole-1-acetic acid

HRID 2233750

反应方程式

HRID 2233750 反应方程式
[OH-].[Na+].[Cl:3][C:4]1[CH:29]=[CH:28][C:7]([O:8][C:9]2[C:17]3[C:12](=[CH:13][CH:14]=[C:15]([S:18]([CH3:21])(=[O:20])=[O:19])[CH:16]=3)[N:11]([CH2:22][C:23]([O:25]C)=[O:24])[C:10]=2[CH3:27])=[CH:6][CH:5]=1.O>C1COCC1>[Cl:3][C:4]1[CH:5]=[CH:6][C:7]([O:8][C:9]2[C:17]3[C:12](=[CH:13][CH:14]=[C:15]([S:18]([CH3:21])(=[O:19])=[O:20])[CH:16]=3)[N:11]([CH2:22][C:23]([OH:25])=[O:24])[C:10]=2[CH3:27])=[CH:28][CH:29]=1

参与物

5

反应物 3

HCID 962聚[6-[4-(4-氰基苯基)苯氧基]己基甲基丙烯酸酯]HCID 14798二甲基对苯二胺二盐酸HCID 866092343-(4-chlorophenoxy)-2-methyl-5-(methylsulfonyl)-1H-indole-1-acetic acid, methyl ester

产物 1

HCID 116611643-(4-Chlorophenoxy)-2-methyl-5-(methylsulfonyl)-1H-indole-1-acetic acid

试剂、催化剂与溶剂 1

HCID 8028四氢呋喃溶剂

实验过程

A solution of 1M sodium hydroxide (1 ml) was added to a stirred mixture of the product from step (iii) (235 mg) in THF (1 ml). After 2 h, water (10 ml) was added and the solution extracted with DCM. The solution was acidified with 2 M hydrochloric acid and extracted with ethylacetate. These later organics were dried and evaporated under reduced pressure. Yield 135 mg

后处理

  1. extractionthe solution extracted with DCM
  2. extractionextracted with ethylacetate
  3. customThese later organics were dried
  4. customevaporated under reduced pressure

来源与证据

ORD记录
ord-b6ce475f2d294a08863291c49d496b3c
来源数据集
uspto-grants-2010_05
专利号
US07709521B2

关联笔记

加载中…