海萝胶 → 1-[[2-(5-Bromo-3-indolyl)-1,1-dimethylethyl]amino]-3-(2-methylphenoxy)-2-propanol hydrochloride

HRID 224894

反应方程式

HRID 224894 反应方程式
[CH3:1][C:2]1[CH:12]=[CH:11][CH:10]=[CH:9][C:3]=1[O:4][CH2:5][CH:6]1[CH2:8][O:7]1.[Br:13][C:14]1[CH:15]=[C:16]2[C:20](=[CH:21][CH:22]=1)[NH:19][CH:18]=[C:17]2[CH2:23][C:24]([CH3:27])([CH3:26])[NH2:25].[ClH:28]>C(#N)C>[ClH:28].[Br:13][C:14]1[CH:15]=[C:16]2[C:20](=[CH:21][CH:22]=1)[NH:19][CH:18]=[C:17]2[CH2:23][C:24]([NH:25][CH2:8][CH:6]([OH:7])[CH2:5][O:4][C:3]1[CH:9]=[CH:10][CH:11]=[CH:12][C:2]=1[CH3:1])([CH3:26])[CH3:27]

参与物

5

反应物 3

HCID 313海萝胶HCID 13259Indole, 3-(2-amino-2-methylpropyl)-5-bromo-HCID 166402-甲苯缩水甘油醚

产物 1

HCID 126196531-[[2-(5-Bromo-3-indolyl)-1,1-dimethylethyl]amino]-3-(2-methylphenoxy)-2-propanol hydrochloride

试剂、催化剂与溶剂 1

HCID 6342乙腈溶剂

实验过程

(2-Methylphenoxymethyl)oxirane, 4.1 g. (0.025 mole) and 6.65 g. (0.025 mole) of 5-bromo-α,α-dimethyl-1H-indol-3-yl-ethaneamine were mixed and heated at 140° for 1 hr. The mixture was then cooled and dissolved in 40 ml. of acetonitrile while still warm. The product was converted to the hydrochloride salt by treatment of the solution with 5 N ethanolic HCl. The solvent was removed by distillation and the residue dissolved in 30 ml. of acetonitrile. The product crystallized from this solution, yield 11.0 g., m.p. 197°-199°. This material was recrystallized from methanol/isopropanol, yield 8.0 g., m.p. 198.0°-200.0° dec. (corr.).

后处理

  1. temperatureheated at 140° for 1 hr
  2. temperatureThe mixture was then cooled
  3. dissolutiondissolved in 40 ml
  4. customThe solvent was removed by distillation
  5. dissolutionthe residue dissolved in 30 ml
  6. customThe product crystallized from this solution, yield 11.0 g
  7. customThis material was recrystallized from methanol/isopropanol, yield 8.0 g

来源与证据

ORD记录
ord-24faa05a5cf64903a1ba4521dbd3f790
来源数据集
uspto-grants-1980_11
专利号
US04234595

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