水合肼 → Indole, 3-(2-amino-2-methylpropyl)-5-bromo-

HRID 224897

反应方程式

HRID 224897 反应方程式
[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[CH2:11][C:12]([CH3:17])([N+:14]([O-])=O)[CH3:13].O.NN>[Ni+2]>[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[CH2:11][C:12]([CH3:17])([CH3:13])[NH2:14]

参与物

4

反应物 2

HCID 24654水合肼HCID 126196615-Bromo-3-(2-methyl-2-nitropropyl)indole

产物 1

HCID 13259Indole, 3-(2-amino-2-methylpropyl)-5-bromo-

试剂、催化剂与溶剂 1

HCID 934镍催化剂

实验过程

5-Bromo-3-(2-methyl-2-nitropropyl)indole, 5.9 g. was reduced with Raney nichel and hydrazine hydrate according to the method of Procedure 67D. The crude product was purified by dissolving in 200 ml. of dilute hydrochloric acid, treatment with activated charcoal, filtering, and basification of the filtrate with 10% aqueous sodium hydroxide. Yield 3.8 g. of white powder, m.p. 150°-155° C.

后处理

  1. customThe crude product was purified
  2. dissolutionby dissolving in 200 ml
  3. filtrationof dilute hydrochloric acid, treatment with activated charcoal, filtering

来源与证据

ORD记录
ord-1e15576f9e24402ea73d6f066ceafe14
来源数据集
uspto-grants-1980_11
专利号
US04234595

关联笔记

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