4-硝基苯基-1,3-二甲酸 → 4-氨基-间苯二甲酸

HRID 2261082

反应方程式

HRID 2261082 反应方程式
[N+:1]([C:4]1[CH:12]=[CH:11][C:7]([C:8]([OH:10])=[O:9])=[CH:6][C:5]=1[C:13]([OH:15])=[O:14])([O-])=O>CO.[Pd]>[NH2:1][C:4]1[CH:12]=[CH:11][C:7]([C:8]([OH:10])=[O:9])=[CH:6][C:5]=1[C:13]([OH:15])=[O:14]

参与物

4

反应物 1

HCID 30624384-硝基苯基-1,3-二甲酸

产物 1

HCID 113558524-氨基-间苯二甲酸收率 87%

试剂、催化剂与溶剂 2

HCID 23938钯催化剂HCID 887(5BETA,17BETA)-17-羟基-17-(甲基-D3)-2'H-雄甾-2-烯并[3,2-C]吡唑-5'(1'H)-酮溶剂

实验过程

To a solution of 4-nitro isophthalic acid (98 g, 0.457 mol) in methanol (5 L) was added Pd/C (20%) and hydrogenated at RT for 4 h. The reaction mixture was filtered through celite and filtrate concentrated under vacuum to give 4-amino isophthalic acid (72 g, 87%) as a solid.

后处理

  1. filtrationThe reaction mixture was filtered through celite and filtrate
  2. concentrationconcentrated under vacuum

来源与证据

ORD记录
ord-7746c22ec091453792c71c5416c07f5c
来源数据集
uspto-grants-2010_12
专利号
US07846925B2

关联笔记

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