[Br-].[F:2][CH:3]([F:34])[O:4][C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][CH:13]=1)[CH:10]([P+](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)[O:9][C:8]2=[O:33].[Cl:35][C:36]1[CH:37]=[N:38][CH:39]=[C:40]([Cl:44])[C:41]=1[CH:42]=O.C(N(CC)CC)C.Cl>C(Cl)Cl>[Cl:35][C:36]1[CH:37]=[N:38][CH:39]=[C:40]([Cl:44])[C:41]=1[CH:42]=[C:10]1[C:11]2[C:7](=[CH:6][C:5]([O:4][CH:3]([F:2])[F:34])=[CH:13][CH:12]=2)[C:8](=[O:33])[O:9]1A solution of (5-difluoromethoxy-3-oxo-1,3-dihydro-isobenzofuran-1-yl)-triphenyl-phosphonium bromide (11.4 g, 21 mmoles), prepared as described in example 96, in dry CH2Cl2 (110 ml), under N2, was added with 3,5-dichloro-4-formyl-pyridine (4.06 g, 23.1 mmoles). The mixture was cooled to 4° C. and added with triethylamine (3.8 ml, 27.3 mmoles) while keeping the temperature below 10° C. At the end of the addition the mixture was stirred at room temperature for 3 hours, then cooled and added with 5% HCl. The organic phase was washed with an aqueous NaCl solution, discoloured with charcoal, filtered over celite and dried to give 14.4 g of the title compound (stoichiometric yield; containing 1 equivalent of triphenylphosphine oxide).
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