乙醇 → 1-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)ethanol

HRID 2294591笔记

反应方程式

HRID 2294591 反应方程式
[C:1]([O:4][CH:5]([C:7]1[CH:16]=[CH:15][C:14]2[C:13]([CH3:18])([CH3:17])[CH2:12][CH2:11][C:10]([CH3:20])([CH3:19])[C:9]=2[CH:8]=1)[CH3:6])(=[O:3])[CH3:2].C(O)C>P([O-])([O-])([O-])=O.C(Cl)(Cl)Cl>[CH3:18][C:13]1([CH3:17])[CH2:12][CH2:11][C:10]([CH3:19])([CH3:20])[C:9]2[CH:8]=[C:7]([CH:5]([OH:4])[CH3:6])[CH:16]=[CH:15][C:14]1=2.[C:1]([O:4][CH:5]([C:7]1[CH:16]=[CH:15][C:14]2[C:13]([CH3:18])([CH3:17])[CH2:12][CH2:11][C:10]([CH3:19])([CH3:20])[C:9]=2[CH:8]=1)[CH3:6])(=[O:3])[CH3:2]

参与物

6

反应物 2

HCID 702乙醇HCID 21474567Acetoxy-1-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)ethane

产物 2

HCID 214744991-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)ethanol收率 88%HCID 21474567Acetoxy-1-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)ethane收率 73%

试剂、催化剂与溶剂 2

HCID 1061无水磷酸二氢钾溶剂HCID 6212三氯甲烷溶剂

反应条件

温度
40 °C

实验过程

6 g of (±)-acetoxy-1-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)ethane, suspended in a mixture of 100 ml of phosphate buffer (0.3M, pH 7) and 1 ml of chloroform, are treated with 0.87 g of Amano P30 lipase with stirring at 40° C. for 3 days. 2.06 g (88%) of the expected product, melting point 61°-2° C. (αD =+27°; c=1, ethanol) and 2.2 g (73%) of acetoxy-1-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)ethane are isolated.

后处理

  1. additionare treated with 0.87 g of Amano P30 lipase

来源与证据

ORD记录
ord-1a8042f86fb6432eb30a6b8012f44f3b
来源数据集
uspto-grants-1997_11
专利号
US05688817

反应笔记

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