异氰酸甲酯 → 涕灭威(铁灭克)

HRID 231663笔记

反应方程式

HRID 231663 反应方程式
[CH3:1][C:2]([S:7][CH3:8])([CH3:6])[CH:3]=[N:4][OH:5].[CH3:9][N:10]=[C:11]=[O:12]>O>[CH3:1][C:2]([S:7][CH3:8])([CH3:6])[CH:3]=[N:4][OH:5].[CH3:9][NH:10][C:11]([O:5][N:4]=[CH:3][C:2]([CH3:6])([S:7][CH3:8])[CH3:1])=[O:12]

参与物

5

反应物 2

HCID 12228异氰酸甲酯HCID 154362-甲基-2-(甲硫基)丙醛肟

产物 2

HCID 2086涕灭威(铁灭克)HCID 154362-甲基-2-(甲硫基)丙醛肟

试剂、催化剂与溶剂 1

HCID 962聚[6-[4-(4-氰基苯基)苯氧基]己基甲基丙烯酸酯]溶剂

实验过程

The carbamoylation step of the process of this invention can be conducted by mixing 2-methyl-2-(methylthio) propionaldehyde oxime with water at a preferred temperature of from about 0° C. to about 30° C. after which a catalyst is optionally added to the mixture. While maintaining the reaction temperature between about 0° C. and 30° C., methyl isocyanate is added with vigorous stirring over a sufficient period of time to provide for substantially complete conversion of 2-methyl-2-(methylthio) propionaldehyde oxime to 2-methyl-2-(methylthio) propionaldehyde O-(methylcarbamoyl) oxime. The carbamoylation step of the process of this invention can provide 2-methyl-2-(methylthio) propionaldehyde O-(methylcarbamoyl) oxime on a yield basis in excess of 90 percent based on the weight of 2-methyl-2-(methylthio) propionaldehyde oxime.

后处理

  1. additionis optionally added to the mixture
  2. additionis added

来源与证据

ORD记录
ord-fd2c4fe8f1b84133abdce1791e63f15a
来源数据集
uspto-grants-1989_07
专利号
US04847413

反应笔记

加载中…