四氢呋喃 → 1-(2-propynyl)-2-trifluoromethyl-(1H)-indol-3-yl methanol

HRID 231838

反应方程式

HRID 231838 反应方程式
[CH2:1]([N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6]([CH:13]=[O:14])=[C:5]1[C:15]([F:18])([F:17])[F:16])[C:2]#[CH:3].O1CCCC1.[BH4-].[K+]>O>[CH2:1]([N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6]([CH2:13][OH:14])=[C:5]1[C:15]([F:18])([F:16])[F:17])[C:2]#[CH:3]

参与物

5

反应物 3

HCID 8028四氢呋喃HCID 4192641硼氢化钾HCID 200321241-(2-propynyl)-2-trifluoromethyl-3-formyl-(1H)-indol

产物 1

HCID 223920981-(2-propynyl)-2-trifluoromethyl-(1H)-indol-3-yl methanol收率 100.3%

试剂、催化剂与溶剂 1

HCID 962聚[6-[4-(4-氰基苯基)苯氧基]己基甲基丙烯酸酯]溶剂

实验过程

5.54 g of 1-(2-propynyl)-2-trifluoromethyl-3-formyl-(1H)-indol, 120 ml of tetrahydrofuran and 20 ml of water were mixed together at +5° and 2 g of potassium borohydride were added in small fractions. The mixture was concentrated to a small volume by distillation under reduced pressure and ethyl ether was added. The organic phase was washed with salted water and concentrated to dryness by distillation under reduced pressure to obtain 5.6 g of 1-(2-propynyl)-2-trifluoromethyl-(1H)-indol-3-yl methanol melting at 90° C.

后处理

  1. concentrationThe mixture was concentrated to a small volume by distillation under reduced pressure and ethyl ether
  2. additionwas added
  3. washThe organic phase was washed with salted water
  4. concentrationconcentrated to dryness by distillation under reduced pressure

来源与证据

ORD记录
ord-656990a9fdd24678bf66af77d0e0c965
来源数据集
uspto-grants-1989_07
专利号
US04849443

关联笔记

加载中…