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碳酸钾 → Dimethyl 1-[6-(2-chloro-4-methoxyphenoxy) hexyl]-4,5-imidazole dicarboxylate
参与物
| 角色 | 名称 | HCID | 投料 |
|---|---|---|---|
| 反应物 | 碳酸钾 | HCID 11430 | — |
| 反应物 | 1H-咪唑-4,5-二甲酸二甲酯 | HCID 76810 | — |
| 反应物 | 2-{[6-(2-Chloro-4-methoxyphenoxy)hexyl]thio}-4,5-dihydrothiazol-4-one | HCID 18921835 | — |
| 溶剂 | N,N-二甲基甲酰胺 | HCID 6228 | — |
| 产物 | Dimethyl 1-[6-(2-chloro-4-methoxyphenoxy) hexyl]-4,5-imidazole dicarboxylate | HCID 19378829 | — |
反应步骤
Stir for 24 hours at room temperature 3.7 gm. dimethyl 4,5-imidazole dicarboxylate, 3.7 gm. of the iodide prepared in Examples 2 and 3, 25 ml. DMF and 2.8 gm potassium carbonate. Remove the solvent, extract the residue with methylene chloride, filter, wash methylene chloride fractions with water, elute on a silica column with 100% methylene chloride then 10% methanol/methylene chloride to recover the title compound.
来源与证据
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 专利号 | US04851423 |
| 来源数据集 | uspto-grants-1989_07 |
| ORD ID | ord-44b726412bb246759a6c6e8ff26056bc |
| 来源说明 | uspto-grants-1989_07 |