Government regulation → 2-Bromo-1-[4-(1H-imidazol-1-yl)phenyl]ethanone hydrobromide

HRID 232309

反应方程式

HRID 232309 反应方程式
[Br:1]Br.[N:3]1([C:8]2[CH:13]=[CH:12][C:11]([C:14](=[O:16])[CH3:15])=[CH:10][CH:9]=2)[CH:7]=[CH:6][N:5]=[CH:4]1>Br.C(O)(=O)C>[BrH:1].[Br:1][CH2:15][C:14]([C:11]1[CH:10]=[CH:9][C:8]([N:3]2[CH:7]=[CH:6][N:5]=[CH:4]2)=[CH:13][CH:12]=1)=[O:16]

参与物

5

反应物 2

HCID 24408Government regulationHCID 823164-咪唑乙酰苯酮

产物 1

HCID 200313102-Bromo-1-[4-(1H-imidazol-1-yl)phenyl]ethanone hydrobromide

试剂、催化剂与溶剂 2

HCID 176醋酸溶剂HCID 260氢溴酸溶剂

实验过程

Add bromine (5.71 mL, 0.111 mol) to a solution of 4'-(1H-imidazol-1-yl)acetophenone (20.75 g, 0.111 mol) in 30-32% HBr in acetic acid. Stir the mixture overnight and collect the crystals. Wash the crystals with ethanol (3×50 mL) and air dry for 2h at room temperature to afford the title compound.

后处理

  1. customcollect the crystals
  2. washWash the crystals with ethanol (3×50 mL) and air
  3. dry with materialdry for 2h at room temperature

来源与证据

ORD记录
ord-27f1074a998940f2a6cf78bb3d89b3ee
来源数据集
uspto-grants-1989_07
专利号
US04851526

关联笔记

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